bio-research/skills/start/SKILL.md
Set up your bio-research environment and explore available tools. Use when first getting oriented with the plugin, checking which literature, drug-discovery, or visualization MCP servers are connected, or surveying available analysis skills before starting a new project.
npx skillsauth add anthropics/knowledge-work-plugins startInstall this skill globally with one command. Works with Claude Code, Cursor, and Windsurf.
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If you see unfamiliar placeholders or need to check which tools are connected, see CONNECTORS.md.
You are helping a biological researcher get oriented with the bio-research plugin. Walk through the following steps in order.
Display this welcome message:
Bio-Research Plugin
Your AI-powered research assistant for the life sciences. This plugin brings
together literature search, data analysis pipelines,
and scientific strategy — all in one place.
Test which MCP servers are connected by listing available tools. Group the results:
Literature & Data Sources:
Drug Discovery & Clinical:
Visualization & AI:
Report which servers are connected and which are not yet set up.
List the analysis skills available in this plugin:
| Skill | What It Does | |-------|-------------| | Single-Cell RNA QC | Quality control for scRNA-seq data with MAD-based filtering | | scvi-tools | Deep learning for single-cell omics (scVI, scANVI, totalVI, PeakVI, etc.) | | Nextflow Pipelines | Run nf-core pipelines (RNA-seq, WGS/WES, ATAC-seq) | | Instrument Data Converter | Convert lab instrument output to Allotrope ASM format | | Scientific Problem Selection | Systematic framework for choosing research problems |
Mention that two additional MCP servers are available as separate installations:
txg-node.mcpb from https://github.com/10XGenomics/txg-mcp/releasestooluniverse.mcpb from https://github.com/mims-harvard/ToolUniverse/releasesThese require downloading binary files and are optional.
Ask the researcher what they're working on today. Suggest starting points based on common workflows:
Wait for the user's response and guide them to the appropriate tools and skills.
testing
Reads a forwarded customer email or ticket, pulls order/refund status from PayPal and account history from HubSpot, drafts a tone-matched reply in the owner's writing voice, and can issue a PayPal refund with explicit owner approval. Use when the user says "draft a response," "answer this customer," "where's my order," or "I want a refund."
development
Prepares tax-season materials for small business owners — framed as deliverables for their accountant, not tax advice. Two modes: (1) quarterly estimated tax calculation — pulls YTD net income from QuickBooks and calculates the federal income tax + self-employment tax liability and quarterly payment due; (2) year-end 1099 prep — scans QuickBooks, PayPal, and Stripe for contractors paid over $600, builds a 1099-NEC candidate list with missing W-9 flags, and produces a plain-English summary a CPA can work from directly. Trigger this skill whenever the user mentions: quarterly taxes, estimated tax payment, how much to set aside for taxes, 1099s, 1099-NEC, year-end tax prep, contractor payments, W-9s, or any phrase suggesting they are preparing for a tax deadline or handing materials to an accountant. Also trigger proactively when a user asks about net profit or YTD income in a context that suggests they are worried about their tax bill.
tools
Prepares tax-season materials — quarterly estimated tax calculation or year-end 1099 prep — and produces an accountant handoff packet. Accepts optional mode and year arguments.
tools
The front door to the Small Business plugin. Listens to what the owner needs right now — vague or specific — and routes them to the best skill or slash command for the moment. Also serves as a guide: explains what's available, suggests what to try next, and adapts recommendations based on stored business context. Trigger whenever the owner asks "what can you do," "help me with my business," "what should I focus on," "I don't know where to start," or any open-ended business request that doesn't clearly match a single skill.