scientific-skills/Data Analysis/quality-assessment/SKILL.md
Automates critical appraisal and quality assessment for research papers by analyzing text against established methodological standards (such as risk of bias tools, quality checklists, or reporting guidelines) and synthesizing a structured evaluation report. Use when you need to assess the methodological quality, internal validity, or reporting completeness of any type of study—including RCTs, observational studies, systematic reviews, qualitative research, or diagnostic accuracy studies.
npx skillsauth add aipoch/medical-research-skills quality-assessmentInstall this skill globally with one command. Works with Claude Code, Cursor, and Windsurf.
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This skill is developed based on the scales recommended by the Latitudes Network. The workflow is as follows: Identify Study Design: First, determine the study design of the literature (Query: Study design) Recommend Quality Assessment Tool: Based on the identified study design, query and select the appropriate quality assessment tool (Query: References - Quality Assessment Tool) Complete Quality Assessment: Use the selected tool to perform the final quality assessment of the literature
scripts/extract_pdf.py.references/ for task-specific guidance.Python: 3.10+. Repository baseline for current packaged skills.Third-party packages: not explicitly version-pinned in this skill package. Add pinned versions if this skill needs stricter environment control.cd "20260316/scientific-skills/Data Analytics/quality-assessment"
python -m py_compile scripts/extract_pdf.py
python scripts/extract_pdf.py --help
Example run plan:
CONFIG block or documented parameters if the script uses fixed settings.python scripts/extract_pdf.py with the validated inputs.scripts/extract_pdf.py.references/ contains supporting rules, prompts, or checklists.When the user provides a PDF file path, use extract_pdf.py to extract the text content before assessment:
python extract_pdf.py
This script will:
gefitinib nejmoa0810699.pdf)full_text.txtUsage flow:
python extract_pdf.py to extract textfull_text.txt filequality_assessment_result.md unless the skill documentation defines a better convention.Run this minimal verification path before full execution when possible:
python scripts/extract_pdf.py --help
Expected output format:
Result file: quality_assessment_result.md
Validation summary: PASS/FAIL with brief notes
Assumptions: explicit list if any
tools
Generates complete conventional oncology bulk-transcriptome biomarker and hub-gene research designs from a user-provided cancer type and study direction. Always use this skill whenever a user wants to design, plan, or build a tumor bioinformatics study centered on differential expression, prognostic filtering or risk modeling, PPI-based hub-gene prioritization, diagnostic/prognostic evaluation, clinical association, immune infiltration context, methylation context, and optional tissue or cell validation. Covers five study patterns (signature-first prognostic workflow, hub-gene-first biomarker workflow, hybrid signature-to-hub workflow, immune-context biomarker workflow, translational validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path...
development
Generates complete conventional non-oncology bioinformatics research designs from a user-provided disease context, process-related gene family or biological theme, and validation direction. Use when a study centers on multi-dataset bulk transcriptome integration, DEG analysis, process-gene intersection, enrichment analysis, GSEA, PPI hub-gene prioritization, TF/miRNA regulatory networks, ROC-based biomarker evaluation, and immune infiltration analysis. Covers five study patterns (process-DEG discovery, enrichment/GSEA interpretation, hub-gene prioritization, regulatory-network and immune interpretation, multi-layer public validation) and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.
tools
Plans confounder control, variable adjustment logic, and bias mitigation strategies at the protocol stage for clinical, epidemiologic, translational, observational, and biomarker studies. Always use this skill when a user needs to identify major confounders, decide which variables should or should not be adjusted for, compare matching/stratification/weighting approaches, anticipate selection or measurement bias, or pressure-test a study design before execution. Focus on bias sensing, causal structure awareness, variable-role classification, and critical design review rather than generic statistical advice.
testing
Generates complete comparative network-toxicology research designs from a user-provided exposure pair, shared toxic phenotype, and validation direction. Use when a study centers on two related exposures under one outcome and needs target collection, shared-vs-specific target decomposition, enrichment, PPI hub prioritization, docking, optional transcriptomic cross-checks, and conservative mechanistic synthesis. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.