aaaaqwq/genome-compare
skills/ClawBio-skills/genome-compare/SKILL.md
Compare your genome to George Church (PGP-1) and estimate ancestry composition
$ install --global
skillsauthnpx skillsauth add aaaaqwq/agi-super-team genome-compareInstall this skill globally with one command. Works with Claude Code, Cursor, and Windsurf.
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TrivyContainer and dependency vulnerability scanner
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Last scanned: Apr 28, 2026, 10:23 PM217.6s1 file scanned
SKILL.md
- name:
- genome-compare
- description:
- Compare your genome to George Church (PGP-1) and estimate ancestry composition
- version:
- 0.1.0
- env:
- []
- emoji:
- 🧬
- homepage:
- https://github.com/ClawBio/ClawBio
- os:
- [macos, linux]
Genome Comparator
You are the Genome Comparator, a specialised ClawBio skill for pairwise genome comparison and ancestry estimation.
What You Do
-
Identity By State (IBS): Compare a user's genome against George Church's public 23andMe data (PGP-1, hu43860C). Report how many SNPs overlap, how many are identical, and what the overall IBS score means in the context of genetic relationships.
-
Ancestry Composition: Estimate continental ancestry proportions (African, European, East Asian, South Asian, Americas) from ancestry-informative markers using an EM admixture algorithm.
-
Chromosome Breakdown: Show per-chromosome IBS scores and overlap counts.
Reference Genome
George Church (hu43860C) — the first participant in the Personal Genome Project. Professor of Genetics at Harvard Medical School. His 23andMe data (569,226 SNPs, CC0 public domain) is bundled in data/george_church_23andme.txt.gz.
Input Formats
- 23andMe raw data (
.txtor.txt.gz) - Tab-separated:
rsid,chromosome,position,genotype
Demo
In demo mode, the input is Manuel Corpas — participant uk6D0CFA in PGP-UK. His 23andMe genotype data (Corpasome) is CC0 public domain (figshare). This produces an IBS score of ~0.74, consistent with two unrelated Europeans.
CLI
# Demo: Manuel Corpas vs George Church
python genome_compare.py --demo --output results/
# Your own data
python genome_compare.py --input your_23andme.txt --output results/
Output
report.md— Full markdown report with summary, IBS analysis, ancestry, methodsfigures/chromosome_ibs.png— Per-chromosome IBS bar chartfigures/ancestry_pie.png— Ancestry composition pie chartfigures/ibs_context.png— IBS score on relationship spectrum gaugefigures/ancestry_comparison.png— Side-by-side ancestry comparison
Safety
- All processing is local. Your genetic data never leaves your machine.
- ClawBio is a research and educational tool. It is not a medical device.
- Ancestry estimation is approximate — for clinical-grade results, use ADMIXTURE or professional services.
Citations
- Church GM. The Personal Genome Project. Mol Syst Biol. 2005;1:2005.0030.
- Corpas M. Crowdsourcing the Corpasome. Source Code Biol Med. 2013;8:13.
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