
Manage Apple Notes on macOS using the `memo` CLI. Use this when users ask to create, list, search, edit, move, or export Apple Notes.
Use this skill whenever the user wants to do anything with PDF files. This includes reading or extracting text/tables from PDFs, combining or merging multiple PDFs into one, splitting PDFs apart, rotating pages, adding watermarks, creating new PDFs, filling PDF forms, encrypting/decrypting PDFs, extracting images, and OCR on scanned PDFs to make them searchable. If the user mentions a .pdf file or asks to produce one, use this skill.
Use this skill any time a .pptx file is involved in any way — as input, output, or both. This includes: creating slide decks, pitch decks, or presentations; reading, parsing, or extracting text from any .pptx file (even if the extracted content will be used elsewhere, like in an email or summary); editing, modifying, or updating existing presentations; combining or splitting slide files; working with templates, layouts, speaker notes, or comments. Trigger whenever the user mentions "deck," "slides," "presentation," or references a .pptx filename, regardless of what they plan to do with the content afterward. If a .pptx file needs to be opened, created, or touched, use this skill.
Medical quality-system and documentation workflow guide for ISO 13485, FDA QMSR, design controls, risk management, CAPA, document control, supplier qualification, complaint handling, and audit preparation. Use when the user asks to plan, review, or gap-assess medical-device or diagnostic quality documentation without asking for legal determinations or regulatory guarantees.
Molecular docking workflow guide and reusable pipeline template for AutoDock Vina, Open Babel, and PyMOL.
Bioinformatics workflow guide for sequence analysis, QC, plotting, structure rendering, and literature search.
Drug-patent landscape workflow guide for searching US patents via the PatentsView API, classifying pharmaceutical claim types (NCE, formulation, method-of-use, polymorph, combination, biologic, process), grouping by patent family and assignee, estimating expiry timelines, and cross-referencing the FDA Orange Book for marketed-drug exclusivity windows. Use when the user asks about patent coverage, IP white-space, patent cliffs, or competitive filing activity around a drug, target, or compound class without asking for legal counsel.
Survival and time-to-event workflow guide for Kaplan-Meier summaries, log-rank tests, and Cox proportional hazards models with reproducible outputs. Use when the user asks for time-to-event analysis, censored data summaries, hazard ratios, or survival-group comparison for research datasets.
Interact with GitHub using the `gh` CLI. Use `gh issue`, `gh pr`, `gh run`, and `gh api` for issues, PRs, CI runs, and advanced queries.
Manage Apple Reminders on macOS using `remindctl` (list, add, edit, complete, delete, and list management). Use when users ask for reminders or task-list operations in Apple Reminders.
Use this skill any time a spreadsheet file is the primary input or output. This means any task where the user wants to: open, read, edit, or fix an existing .xlsx, .xlsm, .csv, or .tsv file (e.g., adding columns, computing formulas, formatting, charting, cleaning messy data); create a new spreadsheet from scratch or from other data sources; or convert between tabular file formats. Trigger especially when the user references a spreadsheet file by name or path — even casually (like "the xlsx in my downloads") — and wants something done to it or produced from it. Also trigger for cleaning or restructuring messy tabular data files (malformed rows, misplaced headers, junk data) into proper spreadsheets. The deliverable must be a spreadsheet file. Do NOT trigger when the primary deliverable is a Word document, HTML report, standalone Python script, database pipeline, or Google Sheets API integration, even if tabular data is involved.
Variant and VCF workflow guide for local SNV, indel, and structural-variant summarization, filtering, and consequence triage. Use when the user asks to inspect a VCF, count mutation classes, filter by VAF or depth, summarize genes or consequences, or prepare a local variant report before downstream annotation.
Pharmaceutical machine-learning workflow guide for library profiling, molecular featurization, benchmark dataset fetch, medicinal-chemistry filtering, and optional pose-generation handoff. Use when the user asks for datamol, molfeat, PyTDC, medchem, compound-library triage, dataset preparation, or chemistry-ML baselines beyond simple descriptor calculation.
Omics and single-cell workflow guide for AnnData, Scanpy-style dataset profiling, PyDESeq2-oriented count checks, pysam alignment inspection, and pyOpenMS mass-spectrometry summaries. Use when the user asks to inspect h5ad files, summarize BAM regions, profile omics count tables, or inventory mzML experiments before deeper modeling.
Query and manage Apple Calendar on macOS via `icalBuddy` (read) and AppleScript (`osascript`) for event creation. Use when users ask about upcoming events or adding calendar events.
Get current weather and short forecasts quickly using `wttr.in` (no API key required). Use when users ask for weather by city/region.
Scientific visualization workflow guide for publication-ready static figures with seaborn or matplotlib and interactive figures with Plotly. Use when the user asks for scientific plots, cohort or assay figures, publication graphics, dashboards, or reusable plotting scripts for research datasets.
Use this skill whenever the user wants to create, read, edit, or manipulate Word documents (.docx files). Triggers include: any mention of "Word doc", "word document", ".docx", or requests to produce professional documents with formatting like tables of contents, headings, page numbers, or letterheads. Also use when extracting or reorganizing content from .docx files, inserting or replacing images in documents, performing find-and-replace in Word files, working with tracked changes or comments, or converting content into a polished Word document. If the user asks for a "report", "memo", "letter", "template", or similar deliverable as a Word or .docx file, use this skill. Do NOT use for PDFs, spreadsheets, Google Docs, or general coding tasks unrelated to document generation.
Find reusable skills from the vercel-labs/skills registry (especially by task keywords), evaluate fit, and suggest how to install/adapt them for DrugClaw.
Bayesian optimization workflow guide for experiment suggestion, condition tuning, and closed-loop parameter search with Gaussian-process surrogates. Use when the user asks which experiment to try next, how to tune reaction or assay conditions, or how to balance exploration versus exploitation over a bounded numeric search space.
Query public biology databases and APIs including UniProt, RCSB PDB, AlphaFold DB, ClinVar, dbSNP, gnomAD, Ensembl, GEO, InterPro, KEGG, OpenTargets, Reactome, and STRING. Use when the user asks to look up protein annotations, structures, variants, population frequencies, pathway knowledge, public datasets, interaction networks, or disease-target evidence.
Computational chemistry workflow guide for DeepChem, PySCF, RDKit, assay-table normalization, PDBbind-style structure datasets, QSAR and structure benchmarks, DrugBank lookup, ligand-only and structure-aware affinity prediction, ADMET triage, bioactivity prediction, virtual screening, and docking follow-up.
Clinical research workflow guide for protocol design, endpoint selection, evidence grading, reporting-guideline selection, statistical planning, and clinical-trial evidence synthesis. Use when the user asks to design or review human-subjects research, trial analyses, observational studies, study protocols, CSRs, or clinical evidence summaries without requesting patient-specific diagnosis or treatment decisions.
Gene regulatory network workflow guide for transcriptomics and single-cell expression matrices using Arboreto, GRNBoost2, and GENIE3. Use when the user asks to infer transcription factor-target links, score regulatory edges, or build a GRN from bulk or single-cell expression data.
Drug-discovery knowledge-graph workflow guide for assembling drug-target-disease-pathway relationship graphs from OpenTargets GraphQL, ChEMBL REST, STRING PPI, and Reactome pathway APIs, then running hub detection, shortest-path queries, and neighborhood expansion with networkx. Use when the user asks to build, query, or visualize a biomedical knowledge graph connecting drugs, targets, diseases, and pathways from real public databases without making clinical claims.
Research-literature workflow guide for evidence-matrix assembly, citation-table normalization, structured review synthesis, and research-gap mapping. Use when the user asks for systematic or scoped literature review workflows, citation cleanup, evidence tables, or manuscript-ready review preparation for drug-discovery and biomedical topics.
Medical data workflow guide for DICOM metadata inspection and basic de-identification, physiological signal analysis with NeuroKit2, and cohort-table profiling for clinical research datasets. Use when the user asks to inspect imaging metadata, summarize ECG/PPG/EDA/RSP/EMG signals, or profile tabular medical datasets without making patient-specific diagnoses or treatment decisions.
Query public drug-discovery and translational-research databases including PubChem, ChEMBL, BindingDB, openFDA, ClinicalTrials.gov, and OpenAlex. Use when the user asks to look up compounds, measured binding affinities, regulatory labels or adverse events, clinical trials, or drug-discovery literature from public APIs and curated exports.
Research-method workflow guide for hypothesis framing, peer-review style critique, reproducibility planning, study-design checks, and scientific-writing structure. Use when the user asks for manuscript critique, research-gap framing, hypothesis generation, reproducibility checklists, or study-planning support that should stay on the research side rather than patient-care decisions.
Statistical modeling workflow guide for hypothesis tests, effect-size reporting, statsmodels regression, diagnostics, and structured result export. Use when the user asks for statistical test selection, OLS or logistic regression, coefficient tables, inference, or reproducible statistical summaries for scientific datasets.
Target research workflow guide for building compact drug-target dossiers across protein identity, disease evidence, known drugs, interaction partners, pathways, and variant constraint signals. Use when the user asks for a target brief, target validation snapshot, or a one-file summary of what is known about a gene or protein target.
Guide for creating effective skills. This skill should be used when users want to create a new skill (or update an existing skill) that extends Claude's capabilities with specialized knowledge, workflows, or tool integrations.